Dr. Oshrit Hoffer

Dr. Oshrit Hoffer

Ph.D., Faculty of Biomedical Engineering, Tel Aviv University

M.Sc., Faculty of Nuclear Engineering, Ben-Gurion University of the Negev

B.Sc., Faculty of Nuclear Engineering, Ben-Gurion University of the Negev

Since 2023 – Senior lecturer at Afeka 

Since 2024 – Head of the School of Electrical Engineering at Afeka

Since 2018 – Lecturer at the School of Electrical Engineering at Afeka

 

Dr. Hoffer has dedicated her research career to combining thermal imaging and machine learning in medical diagnostics, in order to promote innovation at the intersection of technology and healthcare. Her studies include a range of applications – from monitoring tumors and cardiovascular health to the noninvasive diagnosis of liver diseases and evaluation of postoperative complications. Her work has resulted in over 28 publications in leading journals, underscoring her contribution to the field.

At the core of Dr. Hoffer’s research is the use of thermal imaging to evaluate disease states and monitor therapeutic effects, including monitoring heart and vascular structures and analyzing the skin’s microclimate under medical devices. In recent years, she has developed AI-based models for automated diagnosis of diseases such as Crohn’s disease, rectal cancer, and COVID-19 using thermal imaging and deep learning.

Dr. Hoffer’s studies are characterized by significant interdisciplinary collaborations, which have enabled to apply her work in clinical environments, and have led to major achievements in medical diagnostics. She places great importance on training a new generation of engineers and researchers, and brings her research to class through courses she developed in machine learning and control systems, thus exposing students to the latest developments.

In the future, Dr. Hoffer plans to develop portable, AI-enabled diagnostic devices for point-of-care applications in chronic conditions such as diabetes and heart disease, where early detection and regular monitoring are vital.

  1. Ph.D. Dissertation

  • Thesis Subject: Development of Complementary Technologists to Radiation Therapy

  • Ph. D in Biomedical Engineering, Faculty of Biomedical Engineering, Tel-Aviv University

  • Advisors: Prof. Israel Gannot and Prof. Itzhak Kelson

  • Language: English

  • Number of pages: 130

  • Publications: [15] [16] [17]

Accepted For Publication

  • “Novel diagnostic approach for acute pharyngitis: Combining machine learning with thermal imaging “Oshrit Hoffer, Moriya Cohen, Maya Gerstein, Vered Shkalim Zemer, Yael Richenberg, Dima Bykhovsky, Moshe Hoshen, Herman Avner

    • Journal of biophotonics: Q2 (2023), Impact factor 3.2

 

Articled in Refereed Journals

Published

  1. M. Tepper, A*. Shoval*, Oshrit Hoffer, H*. Confino, M. Schmidt, I. Kelson, Y. Keisari, I. Gannot, “Thermographic investigation of tumor size and its correlation to tumor relative temperature in mice with transplantable solid breast carcinoma”, J. Biomed. Opt., 2013

    • DOI: 10.1117/1.JBO.18.11.111410

    • Journal Details: Q1 (2013), Impact factor 3.39

 

  1. Oshrit Hoffer; M. Ben-David; E. Katz; D.Kirshenbaum; D. Alezra; Y. Zimmer; I. Kelson; I. Gannot, “Thermal imaging as a tool for evaluating tumor treatment efficacy”, J. of Biomedical Optics, 2018.

    • DOI: 10.1117/1.JBO.23.5.058001

    • Journal Details: Q1 (2018), Impact factor 2.85

  2. O. Hazan, L. Sternik, D. Waiss, M. Eldar, Oshrit Hoffer, O. Goitein, R. Koperstein, E. Konen, Z. Blechman, “An Innovative Appendage Invagination Procedure to Reduce Thrombus Formation- A Numerical Model”, Computer Methods in Biomechanics and Biomedical Engineering, 2018.

    • DOI: 10.1080/10255842.2018.1466116

    • Journal Details: Q2 (2019), Impact factor 1.61

 

  1. A. Gefen, L. Peko Cohen, G. Amrani, Oshrit Hoffer, Z. Ovadia-Blechman, “The roles of infrared thermography in pressure ulcer research with focus on skin microclimate induced by medical devices and prophylactic dressings”, Wounds International, 2019; 10 (1), 8-15. Invited article.

    • Citations: 13 (GS), Journal rank & I.F.: not available

 

  1. L. Peko Cohen, Z. Ovadia-Blechman, Oshrit Hoffer, A. Gefen, “Dressings cut to shape alleviate facial tissue loads while using an oxygen mask”, International wound journal, 2019; 16(3), 813-826.

    • DOI: 10.1111/iwj.13101

    • Top Cited Article 2019-2020

    • Journal Details: Q1 (2019), Impact factor 2.825

 

  1. R.Y. Brzezinski, Z. Ovadia-Blechman, N. Lewis, N. Rabin, Y. Zimmer, L. Levin-Kotler, O. Tepper- Shaihov, N. Naftali-Shani, O. Tsoref, E. Grossman, J. Leor & Oshrit Hoffer, “Non-invasive thermal imaging of cardiac remodeling in mice”, Biomedical Optics Express, 2019: 10(12), 6189-6203. Editor's Pick.

 

  1. L. Gavish*, Oshrit. Hoffer*, N. Rabin, M. Halak, S. Shkilevich, Y. Shayovitz, G. Wiezman, B. Gavish, Z. Ovadia-Blechman, “Microcirculatory response to photobiomodulation is dependent on the baseline skin temperature in healthy volunteers: A randomized controlled study”. Lasers in Surgery and Medicine. 2020.

 

  1. G. Amrani, L. Peko, Oshrit Hoffer, Z. Ovadia‐Blechman, A. Gefen, "The microclimate under dressings applied to intact weight‐bearing skin: infrared thermography studies”. Clinical Biomechanics, 2020; 75:104994.

 

  1. Ben-David, M., Oshrit Hoffer, Kirshenabum, D., Katz, E., Alezra, D., Symon, Z., ... & Gannot, I., “Thermal Monitoring of Tumor and Tissue State During Radiation Therapy–The complexed case of Radiation Recall”, Critical Reviews™ in Biomedical Engineering.

    • DOI: 10.1615/CritRevBiomedEng.2020034233

    • Journal Details: Q3 (2020), Impact factor 1.10

  2. R Y. Brzezinski, L. Levin-Kotler, N. Rabin, Z. Ovadia-Blechman, Y. Zimmer, A. Sternfeld, J. M. Finchelman, R. Unis, N.Lewis, O. Tepper-Shaihov, N. Naftali-Shani, N.Balint-Lahat, M. Safran, Z. Ben-Ari, E. Grossman, J. Leor & Oshrit Hoffer, "Automated thermal imaging for the detection of fatty liver disease". Nature Scientific Reports, ‏ 2020 10.1 :1-11

 

  1. Lea Peko, Zehava Ovadia-Blechman, Oshrit Hoffer, Amit Gefen, “Physiological measurements of facial skin response under personal protective equipment", Journal of the Mechanical Behavior of Biomedical Materials Volume 120, 2021.

 

  1. Zehava Ovadia-Blechman*, Oshrit Hoffer*, Moshe Halak*, Karin Adrai, Yair Zimmer, Daniel Silverberg, Neta Rabin. "Assessment of blood distribution in response to post-surgical steal syndrome: A novel technique based on Thermo-Anatomical Segmentation", Journal of Biomechanics, Volume 119, 2021.

 

  1. Lea Peko, Zehava Ovadia-Blechman, Oshrit Hoffer, Amit Gefen, “Physiological measurements of facial skin response under personal protective equipment", Journal of the Mechanical Behavior of Biomedical Materials, Volume 120, 2021.

 

  1. Lilach Gavish, Rose Raizman, Oshrit Hoffer, and S. David Gertz, “Photobiomodulation for Diabetic Foot Ulcers? Show Me!”, Laser Surgery Pages: 631–633, October 2021. Invited article

  2. Rafael Y. Brzezinski, Neta Rabin, Nir Lewis, Racheli Peled, Ariel Kerpel, Avishai M. Tsur, Omer Gendelman, Nili Naftali-Shani, Irina Gringauz, Howard Amital, Avshalom Leibowitz, Haim Mayan, Ilan Ben-Zvi, Eyal Heller, Liran Shechtman, Ori Rogowski, Shani Shenhar-Tsarfaty, Eli Konen, Edith M. Marom, Avinoah Ironi, Galia Rahav, Yair Zimmer, Ehud Grossman, Zehava Ovadia-Blechman, Jonathan Leor & Oshrit Hoffer, "Automated processing of thermal imaging to detect COVID-19”. Sci Rep 11, 17489 (2021).

 

  1. Shai Bogomilsky, Oshrit Hoffer, Guy Shalmon, Mickey Scheinowitz, “Preliminary study of thermal density distribution and entropy analysis during cycling exercise stress test using infrared thermography”. Sci Rep 12, 14018 (2022).

 

  1. Oshrit Hoffer, Tatiana Rabin, Rony-Reuven Nir, Rafael Y. Brzezinski, Yair Zimmer, Israel Gannot. “Automated Thermal Imaging Monitors the Local Response to Cervical Cancer Brachytherapy", Journal of Biphotonics, September 2022

  2. Oshrit Hoffer, Josef Haik, Rony-Reuven Nir Yuval Beck, Bar Kofler, Eilon Heyman, Oz Golan, Zehava Ovadia-Blechman, “The Effect of External Heating on Silicone-Gel Breast Implants: May Heat Exposure Precipitate Burns and Implant-Related Complications?”, Plastic and reconstructive surgery Nov 2022.

 

  1. Dan Carter, Ahmed Albshesh, , Carmi Shimon, Batel Segal, Alex Yershov, Uri Kopylov, Adele Meyers, Rafael Y Brzezinski, Shomron Ben Horin & Oshrit Hoffer, "Automatized Detection of Crohn’s Disease in Intestinal Ultrasound Using Convolutional Neural Network", Inflammatory Bowel Diseases, 2023;, izad014,

 

  1. Gavish, L., Kandel, L., Rivkin, G., Gertz, S. D., & Hoffer, O. (2023). Natural history of changes in knee skin temperature following total knee arthroplasty: a systematic review and meta-analysis. Scientific reports, 13(1), 6810.

 

  1. Ovadia-Blechman, Z., Hauptman, Y., Rabin, N., Wiezman, G., Hoffer, O., Gertz, S. D., Gavish B & Gavish, L. (2023). Morphological features of the photoplethysmographic signal: a new approach to characterize the microcirculatory response to photobiomodulation. Frontiers in Physiology, 14, 1175470.‏

    • Journal Details: Q1 (2023), Impact factor 4.134

 

  1. Fink, N., Bogomilsky, S., Raz, A., Hoffer, O., & Scheinowitz, M. (2023). Thermographic Changes following Short-Term High-Intensity Anaerobic Exercise. Life, 13(11), 2175.‏

    • Journal Details: Q1 (2023), Impact factor 3.2

  2. Hoffer, O., Brzezinski, R. Y., Ganim, A., Shalom, P., Ovadia‐Blechman, Z., Ben‐Baruch, L., ... & Rabin, N. (2024). Smartphone‐based detection of COVID‐19 and associated pneumonia using thermal imaging and a transfer learning algorithm. Journal of Biophotonics, e202300486.‏

    • Journal Details: Q2 (2023), Impact factor 3.2

 

  1. Muller, I., Ovadia-Blechman, Z., Moyal, N., Darchi, N., Hoffer, O., Halak, M., & Rabin, N. (2024). Combining thermal imaging and machine learning to noninvasively characterize palm perfusion during local blood pressure changes. Biomedical Signal Processing and Control, 92, 106109.‏

    • Journal Details: Q1 (2023), Impact factor 4.9

 

  1. Hoffer, O., Cohen, M., Gerstein, M., Zemer, V. S., Richenberg, Y., Nathanson, S., & Cohen, H. A. (2024). IMAJ| volume 26. Journal 5, May, 299-303.‏

    • Journal Details: Q3 (2023), Impact factor 1.8 26

    • DOI: https://doi.org/10.1007/s10151-024-02917-3

    • Journal Details: Q1 (2023), Impact factor 2.7Carter, D., Bykhovsky, D., Hasky, A I. Mamistvalov, Y. Zimmer, E. Ram & O. Hoffer. Convolutional neural network deep learning model accurately detects rectal cancer in endoanal ultrasounds. Tech Coloproctol 28, 44 (2024).

  2. Davidov, Y., Brzezinski, R. Y., Kaufmann, M. I., Likhter, M., Hod, T., Pappo, O., Zimmer, Y., Ovadia-Blechman, Z., Rabin, N., Barlev, A., Berman, O., Ben Ari, Z., & O. Hoffer. (2024). Incorporating artificial intelligence in portable infrared thermal imaging for the diagnosis and staging of nonalcoholic fatty liver disease. Journal of biophotonics, e202400189. Advance online publication.

 

B. Articled in Conference Proceedings

  1. Davidov, Y., Brzezinski, R., Kaufmann, M., Likhter, M., Cohen-ezra, O., Zimmer, Y., ... & Hoffer, O. (2023). Incorporating artificial intelligence in portable infrared thermal imaging for the diagnosis and staging of non-alcoholic fatty liver disease. Journal of Hepatology, 78, S719.‏

  2. Rabin, T., Moyal, N., Zimmer, Y., Kohen, T., Rosenberg, S., Rozenfeld, A., ... & Hoffer, O. (2024). 225 Thermal profiling of cervical carcinoma patients undergoing brachytherapy: a novel diagnostic approach.‏

  3. Gavish, L., Rabin, N., Spitzer, E., Friedman, I., Lowe, J., Gam, A., Yaish, L., Ovadia-Blechman, Z., Hoffer, O., Eisenkraft, A., Gertz, S.D., and Barzilay, Y. “Anterior Knee Pain: A New Look at the Role of Gender and Age”, 2022 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS), March 22-26, Chicago Illinois, USA, Poster.

  4. Gavish, L., Kandel, L., Rivkin, G., Gertz, S.D., Hoffer, O., “What Can We Learn from the Temporal Changes in Knee Skin Temperature Following Total Knee Arthroplasty? - A Systematic Review and Meta-Analysis”, The 23rd EFORT annual congress 2022 June 22-24, Lisbon, Portugal

  5. Gavish, L., Kandel, L., Rivkin, G., Perets, I., Yoav, M., Liebergall, M., Gertz, S.D., & Hoffer, O., “All that is Swollen is not Cold - Thermal Imaging following Total Knee Arthroplasty - A Cross Sectional Diagnostic Study”, Association of Bone and Joint Surgeons (ABJS) annual meeting. September 29 – October 3, 2021, USA, Oral Presentation.

  6. Gavish, L., Kandel, L., Rivkin, G., Perets, I., Yoav, M., Liebergall, M., Gertz, S.D., & Hoffer, O., “Thermal Imaging following Total Knee Arthroplasty - A Cross Sectional Diagnostic Study”, 13th Biennial Congress of ISAKOS (International Society of Arthroscopy, Knee Surgery, and Orthopedic Sport Medicine), November 2021, Cape Town, South Africa (Virtual), Oral presentation.

  7. Kandel, L., Gavish, L., Rivkin, G., Perets, I., Yoav, M., Liebergall, M., Gertz, S.D., & Hoffer, O., “Thermal Imaging for Evaluation of Clinical Outcome Following Total Knee Arthroplasty– A Cross Sectional Diagnostic Study”, 40th Annual Meeting of the Israel Orthopedic Association, December 3-4, 2020, Tel-Aviv, Israel (Virtual) Oral Presentation.

  8. R Y Brzezinski, N Rabin, N Lewis, R Peled, A Tsur, A Kerpel, E M Marom, S Shenhar-Tsarfaty, N Naftali-Shani, G Rahav, E M Grossman, Y Zimmer, Z Ovadia-Blechman, J Leor & O. Hoffer, “Automated processing of thermal imaging to detect COVID-19 and microvascular dysfunction”, European Heart Journal, Volume 42, Issue Supplement_1, October 2021

  9. R.Y. Brzezinski, Z. Ovadia-Blechman, N. Lewis, N. Rabin, Y. Zimmer, L. Levin-Kotler, O. Tepper-Shaihov, N. Naftali-Shani, O. Tsoref, E. Grossman, J. Leor & O. Hoffer, “Non-Invasive Thermal Imaging Detects Cardiac Remodeling in Mice”, 9th ILANIT/FISEB Conference, Eilat, February 2020.  

  10. N. Darchi, N. Moyal, O. Hoffer, N. Rabin. B. Gavish, Z. Ovadia-Blechman, “Characterization of the microcirculatory response to gravity-induced changes by noninvasive thermal imaging”, BIOMEDICAL ENGINEERING 2020, International Conference of ISMBE, Haifa, February 2020.

  11. Z. Ovadia-Blechman, O. Hoffer, N. Rabin, M. Halak, Y. Shayovitz, S. Shkilevich, , G. Wiezman, O. Haim, B. Gavish, L. Gavish, “Enhanced ,microcirculatory blood flow in response to photobiomodulation: The role of skin temperature and the bilateral effect” , The 9th International Bio-Fluid Mechanics and Vascular Mechano-Biology Symposium, Tucson, Arizona, February 2020.

  12. O. Hoffer, L. Gavish, Z. Ovadia-Blechman, G. Weizman, E. Katz, Y. Barzilay, E. Spizer, I. Friedman, N. Mahervax, A. Gam, N. Rabin, “Development and Assessment of an Algorithm for Diagnosis of Knee Pathologies in Combat Soldiers Based on Non-Invasive Infrared Thermal Imaging”, The 15th Annual Conference in Military Medicine Research, Jerusalem, November 2019.

  13. O. Hoffer, L. Gavish, Z. Ovadia-Blechman, G. Weizman, E. Katz, Y. Barzilay, E. Spizer, I. Friedman, N. Mahervax, A. Gam, N. Rabin, “Development and Assessment of an Algorithm for Diagnosis of Knee Pathologies in Combat Soldiers Based on Non-Invasive Infrared Thermal Imaging”, The 15th Annual Conference in Military Medicine Research, Jerusalem, November 2019.

  14. R.Y. Brzezinski, Z. Ovadia-Blechman, N. Lewis, Y. Zimmer, L. Levin-Kotler, O. Tepper-Shaihov, N. Naftali-Shani, O. Tsoref, E. Grossman, J. Leor & O. Hoffer, “Non-Invasive Thermal Imaging Detects Left Ventricular Remodeling in Mice”, Annual conference of Israel Heart Society 2019, Tel-Aviv, April 2019.  

  15. O. Hoffer, N. Rabin, L. Gavish, M. Halak, O. Haim, Y. Shayovitz, S. Shkilevich, B. Gavish, Y. Zimmer, Z. Ovadia-Blechman, “Characterization of skin temperature changes in response to photobiostimulation using thermal imaging: A thermo-anatomical correlation”, Artery 2019, Budapest, Hungary, October 2019.  

  16. Y. Rafael Brzezinski, Z. Ovadia-Blechman, N. Lewis, Y. Zimmer, L. Levin-Kotler, O. Tepper-Shaihov, N. Naftali-Shani, O. Tsoref, E. Grossman, J. Leor & O. Hoffer, “Non-Invasive Thermal Imaging Detects Left Ventricular Remodeling in Mice”, Annual conference Cardiology Society 2019, France, September 2019.  

  17. G. Amrani, L.Peko-Cohen, O. Hoffer, Z. Ovadia-Blechman, A. Gefen, “A Novel Infrared Thermography Method for Evaluation of Dressing-Induced Skin Microclimate Conditions”, EPUAP 2019, France, September 2019.

  18. O. Hoffer, Y. Beck, B. Kofler, J. Haik, E. Heyman, N. Rabin, O. Golan, Z. Ovadia-Blechman, “Evaluation of thermal changes in silicone implants effected by external heating”, BIOMEDICAL ENGINEERING 2019, International Conference of ISMBE, Haifa, February 2019.

  19. L. Peko-Cohen, Z. Ovadia-Blechman, O. Hoffer, A. Gefen, “Dressings Cut to Shape Alleviate Facial Tissue Loads while Using an Oxygen Mask”, BIOMEDICAL ENGINEERING 2019, International Conference of ISMBE, Haifa, February 2019.  

  20. L. Gavish, O. Hoffer, O. Haim, N. Rabin, Y. Shayovitz, S. Shkilevich, M. Halak,B. Gavish, Y. Zimmer, Z. Ovadia-Blechman, “Individual skin temperature is associated with the microcirculatory response to photobiomodulation: A randomized controlled study”, BIOMEDICAL ENGINEERING 2019, International Conference of ISMBE, Haifa, February 2019.

  21. L. Gavish, O. Hoffer, S. Shkilevich, Y. Shayovitz, M. Halak, B. Gavish, N. Rabin, Z. Blechman, “How hot are your hands? Microcirculatory response to photobiomodulation is dependent on the baseline skin temperature: On the way to personalized protocols – a randomized controlled study”, WALT 2018, Nice, France, October 2018.

  22. Tatiana rabin, O.Hoffer, M.Ben-David and Israel Gannot, "Monitoring the response of cervical cancer during brachytherapy", Annual 2018 conference of ESTRO, Barcelona

  23. O. Hoffer, M. Ben-David, E. Katz, D. Kirshenabum, D. Alezra, I. Kelson, I. Gannot, “Thermal Imaging as a Tool for Radiotherapy Treatment Monitoring”, Presented at the ISMBE, February 2018, Haifa, Israel.

  24. O. Hoffer; M. Ben-David; E. Katz; M. Sholomov; I. Kelson and I. Gannot, “A portable thermal imaging device as a feedback system for breast cancer treatment”, SPIE BiOS. 27 January - 1 February 2018 San Francisco, California United States.

  25. O. Hoffer, M. Tepper, A. Shoval, H. Confino, M. Schmidt, I. Kelson, Y. Keisari, I. Gannot, “Thermographic assessment of tumor size in mice injected tumor”, The fiftieth annual meeting of the Israeli Society for Cancer Research (ISCR), May 23, 2013, Ben-Gurion University of the Negev, Israel.

  26. O. Hoffer, M. Tepper, A. Shoval, H. Confino, M. Schmidt, I. Kelson, Y. Keisari, I. Gannot, “Thermographic investigation of tumor size”, The International Congress of Imaging Science (ICIS), May 12-14, 2014, Dan Panorama Hotel, Tel-Aviv, Israel.

  27. O. Hoffer, J. Schwartz., R. Mordechai, S. Mark, “Developing a multi system tool for disease identification”, Medical Physics – Present and Future, November 2007, Ben Gurion University, Israel.

  28. O. Avraham, I. Orion, “Upgrading the EGS4 Monte Carlo code system for ultra-soft X-ray simulations”, Presented at the 22nd Conference of the Nuclear Societies, February 2004, Dead Sea, Israel.

  29. O. Avraham, I. Orion, “Monochromatic X-ray Microbeam Cell Culture Irradiation Combined with Longitudinal-Strong Magnetic-Field Confinement”, Annual 2001 conference of ISMBE Israel Society for Medical and Biological Engineering, Ben-Gurion University of the Negev, Israel.

 

C. Other Scientific Publications

Published

Technical Reports:

  1. I. Orion, Oshrit. Avraham, “Technical Report: Monte Carlo Simulations for Soft X-ray Microspectroscopy Using the Upgraded EGS4 Code”, System Synchrotron Radiation News ‏2007.

D. Other Publications

  1. Publication in Maariv newspaper

Link: https://www.maariv.co.il/business/tech/Article-819167